[Drugs used in tuberculosis and leprosy].

Combined chemotherapy of multibacillary leprosy patients.

380 multibacillary leprosy patients were treated with combined chemotherapy at Anandaban leprosy hospital in Nepal. The drugs used were Rifampicin, Dapsone, Clofazamine and Iso-prodian. This treatment is modelled on the short course chemotherapy of tuberculosis. A remarkable clinical and bacteriological improvement was observed in all patients. Group A patients were bacteriologically negative a...

Tuberculosis in Immigrants to Cartagena de Indias, Colombia

Introduction: Tuberculosis (TB) affects vulnerable populations. Immigrants have contributed to the increased incidence of TB. In this population, TB has some common characteristics that can lead to increased resistance to anti-TB drugs and undesired outcomes. In Cartagena de Indias, Colombia, an increase in TB cases has been observed in immigrants. Our objective is to describe ...

Effect of immunosuppressive drugs on infection in mice by M. marinum (balnei), M. tuberculosis and M. leprae.

Chemotherapy of murine leprosy. II. The effects of streptomycin, sulfones and isonicotinylhydrazines on mouse leprosy.

The effectiveness of the sulfones in the treatment of human leprosy is well known (9, 11). The antileprosy activity of streptomycin has been reported by several workers (6, 9, 11, 18). However, the action of these drugs on murine leprosy is stilI not established. Prom in has been reported to have an inhibitory action on rat leprosy (2, 5) and on mouse leprosy (8). Diasone has been considered ef...

Approaches to clinical research.

The effi cacy of the sulfones in the trea tment of leprosy was proven in a controll ed study by Doull et al. (5), but, because it takes several years to arrest the disease in a case of leprosy and make it bacteriologically negative, search for more effective drugs has continued to the present time. Several drugs found effective in human leprosy have been evaluated by Doull (5) and Doull et aT. ...